77 Massachusetts Avenue
Cambridge, MA 02139
Research Website: http://almlab.mit.edu
- B.S., 1995, University of Illinois, Urbana
- M.S., 1997, University of California, Riverside
- Ph.D., 2001, University of Washington, Seattle
- Postdoc, 2005, University of California, Berkeley/Lawrence Berkeley National Laboratory
Research in my group includes both computational/theoretical and experimental approaches to understanding the evolution of microorganisms, emphasizing a ‘systems-level’ perspective. Some areas of special interest include:
- Tools for detecting natural selection in microbes
- The evolutionary origin of gene families
- Mining metagenomic sequence data
- Experimental evolution of microbes
- Modeling bacterial ecology
- Gene regulatory networks in bacteria
- Protein structure and design
I have enjoyed teaching a variety of classes at MIT, spanning my own diverse interests in microbiology, computer algorithms, and thermodynamics of biomolecules. I am currently looking forward to teaching a new class on microbial evolution and genetics.
- Shapiro B.J. and Alm E.J. Comparing Patterns of Natural Selection Across Species Using Selective Signatures. PloS Genetics. In press.
- Price, M.N., Arkin, A.P. and Alm, E.J.(*) (2006) The life-cycle of operons. PLoS Genetics, 2, e96
- Alm, E., Huang, K. and Arkin, A. (2006) The evolution of two-component systems in bacteria reveals different strategies for niche adaptation. PLoS Comput Biol, 2, e143.
- Alm, E. and Arkin, A.P. (2003) Biological networks. Curr Opin Struct Biol, 13, 193-202.
- Alm, E. and Baker, D. (1999) Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures. Proc Natl Acad Sci U S A, 96, 11305-11310.